![]() ![]() Still, the potential is always there, particularly among young children or patients with GI tract obstruction that may initially manifest as constipation.Įncopresis. ![]() This particular side effect isn't directly related to MiraLAX, which is taken in smaller doses. These tears and related bleedings may occur in the mucus membrane of the lower part of the esophagus or upper part of the stomach. Įsophageal perforations: Also known as Mallory-Weiss tear, esophageal perforations associated with polyethylene glycol-based electrolyte lavage solution have been reported as far back as 1991. ![]() Links between PEG and urticaria have been documented as far back as 1991. This life-threatening allergic reaction may develop within minutes or even seconds after ingesting a PEG-containing laxative. Children are particularly susceptible to hives and face a grave risk of anaphylaxis. Urticaria: PEG may cause allergy-related hives (urticaria) - raised red welts on the surface of the skin. This particular “side effect” is most likely related to the hydrolyzed (separated in water solution) molecules of ethylene glycol. For these reasons, PEG is contraindicated for patients with kidney disease. Nephrotoxicity: PEG has been connected to nephrotoxicity - a euphemism for kidney damage - when used as a drug solvent or when applied to the skin. In addition to neurotoxicity, the following serious complications have been associated with polyethylene glycol-containing laxatives: PEG is more like lead or mercury - slow-acting, insidious, and difficult to pin down conclusively onto various “slow-brewing” neurological disorders. So are snake venom, curare, botulinum, and tetanus. Lead, mercury, and arsenic are some of the best-known neurotoxins. No surprise there considering the quotation above. These conditions result from PEG's direct (through cellular damage) and indirect (through malnutrition of essential micronutrients) neurotoxicity. The term “neuropsychiatric events” in the FDA's safety alert refers to neurologic disorders of the central and peripheral nervous systems such as autism, dementia, depression, schizophrenia, multiple sclerosis, Alzheimer’s and Parkinson’s diseases, and similar others. Ingestion of sufficient amounts can be fatal.” It and its toxic byproducts first affect the central nervous system (CNS), then the heart, and finally the kidneys. ![]() “Ethylene glycol is chemically broken down in the body into toxic compounds. According to the National Institute for Occupational Safety and Health, it is an extremely toxic substance: On its own, ethylene glycol is used in automotive antifreeze and brake fluid. Polyethylene glycol is made by stringing together molecules of ethylene glycol into a large polymer chain, hence the prefix poly-, Greek for many. The cutout from the MiraLAX-related posting on the FDA's website. The “3350” qualifier refers to the molecular weight of this particular variant of PEG. ”īesides MiraLAX, this warning also applies to Movicol, Dulcolax, Colyte, Colovage, Co-Lav, Clensz-Lyte, ClearLax, GoLYTELY, GaviLyte C, GlycoLax, Go-Evac, GlycoPrep, E-Z-Em Fortrans, Halflytely, Lax-a-Day, LaxLyte, MoviPrep, Macrogol, NuLytely, OCL, Peg-Lyte, Prep Lyte, Softlax, TriLyte, and all other brands with Polyethylene Glycol 3350 (PEG for short) as their active ingredient. Are you getting mad or forgetful after taking a laxative? Well, according to the US Food and Drug Administration, that's what certain best-selling laxatives can do to you.īack in December of 2011, the FDA placed MiraLAX - a polyethylene glycol-containing blockbuster drug marketed by Merck & Co - on its Adverse Event Reporting System (AERS) in connection to “neuropsychiatric events. ![]()
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